Gabriel Jesus has been out since he underwent knee surgery last December and is a long-term absentee.
Nketiah and Trossard picked up knocks in recent weeks.
Gabriel Martinelli started upfront against Sporting in the Europa League on Thursday.
The Gunners currently hold a five-point lead at the top of the table, but face a stern test against in-form Fulham.
Eddie is out too so we have Gabi out, Eddie out and Leo is out so we have to adapt in this period of the season.
“We have different options, we can play with a winger more as a 9, we can play with a false 9, let's see,” Arteta told Sky Sports.