Health
MSF caution against surge in malnutrition cases in Northern Nigeria
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By Francesca Hangeior.
Médecins Sans Frontières (MSF), also known as Doctors Without Borders, has cautioned against a devastating surge in severe malnutrition cases among children in northern Nigeria.
The MSF while lamenting that the development has ignited a health crisis stressed the need to guide against an early peak in the lean season.
Dr. Simba Tirima, MSF’s Country Representative in Nigeria, disclosed this in Abuja on Tuesday during the presentation of the international organization’s 2023 Activity Report and the essential medical data for the first quarter of 2024.
The report revealed an alarming 100% increase in admissions in some locations, surpassing last year’s figures.
In April 2024, MSF’s medical team in Maiduguri, northeast Nigeria, admitted 1,250 severely malnourished children with complications to their inpatient therapeutic feeding center, doubling the figure from April 2023.
According to the report, the treatment facility was forced to urgently scale up its capacity, accommodating 350 patients by the end of May, far exceeding the 200 beds initially designated for the peak malnutrition season in July and August.
Similarly, MSF-operated facilities in Bauchi state’s Kafin Madaki hospital and Zamfara state’s Shinkafi and Zurmi have recorded significant increases in admissions of severely malnourished children.
In Kebbi state, the therapeutic feeding center documented a rise of over 20% in inpatient admissions from March to April.
MSF inpatient facilities in major cities like Kano and Sokoto are also reporting alarming surges of 75% and 100%, respectively.
In his remarks, Dr. Tirima stated that despite the alarming situation, the overall humanitarian response remains inadequate.
He said, “We are alarmed by the reduction in aid at these critical times. Reducing nutritional support to only severely malnourished children is akin to waiting for a child to become gravely ill before providing care.
“We’ve been warning about the worsening malnutrition crisis for the last two years. 2022 and 2023 were already critical, but an even grimmer picture is unfolding in 2024. We can’t keep repeating these catastrophic scenarios year after year. What will it take to make everyone take notice and act?
“We are resorting to treating patients on mattresses on the floor because our facilities are full. Children are dying. If immediate action is not taken, more lives hang in the balance. Everyone needs to step in to save lives and allow the children of northern Nigeria to grow free from malnutrition and its disastrous long-term, if not fatal, consequences.”
Meanwhile, he noted that other non-profit organizations active in the north are also overwhelmed.
Recall that the United Nations and Federal Government issued an urgent appeal in May for $306.4 million to address the pressing nutritional needs in Borno, Adamawa, and Yobe states.
However, Dr. Tirima argued that this amount will be insufficient, neglecting other parts of northern Nigeria where needs also outweigh the current capacity of organizations to respond adequately.
Health
‘Blessed’: US Woman Sees Second Chance In Life After Pig Kidney Transplant
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Towana Looney donated a kidney to her mother in 1999 only for the remaining one to fail years later due to pregnancy complications.
Now, the 53-year-old from Alabama has become the latest recipient of a gene-edited pig kidney — and is currently the only living person in the world with an animal organ transplant, New York’s NYU Langone hospital announced Tuesday.
“I’m overjoyed, I’m blessed to have received this gift, this second chance at life,” Looney said during a press conference, held three weeks after the procedure.
Xenotransplantation, transplanting organs from one species to another, has long been a tantalizing yet elusive scientific goal. Early experiments on primates faltered, but recent advances in gene editing and immune system management have brought the dream closer to reality.
Pigs have emerged as the ideal donors: they grow quickly, produce large litters and are already part of the human food supply.
Advocates hope this approach can help address the severe organ shortage in the United States, where more than 100,000 people are waiting for transplants, including over 90,000 in need of kidneys.
A last chance
Looney had been living with dialysis since December 2016 — eight grueling years. High blood pressure caused by preeclampsia had taken its toll, leaving her with chronic kidney disease.
Despite receiving priority on transplant waiting lists as a living donor, her search for a compatible kidney was a frustrating dead end. Her unusually high levels of harmful antibodies made rejection almost inevitable, and as her body lost viable blood vessels to support dialysis, her health declined.
Out of options, Looney applied to join a clinical trial for pig kidney transplants, and finally underwent the seven-hour surgery on November 25.
Asked how she felt afterward, Looney’s joy was infectious. “I’m full of energy, I’ve got an appetite… and of course, I can go to the bathroom. I haven’t been going in eight years!” she laughed, adding that she plans to celebrate at Disney World.
Jayme Locke, a surgeon on the transplant team, described the results with awe. “The kidney functioned essentially exactly like a kidney from a living donor,” she said, adding that Looney’s husband saw a rosiness in her cheeks for the first time in years.
“That is the miracle of transplantation.”
Cautious optimism
Looney’s surgery is the third time a gene-edited pig kidney has been transplanted into a human who is not brain dead.
Rick Slayman, the first recipient, died in May, two months after his procedure at Massachusetts General Hospital. The second, Lisa Pisano, initially showed signs of recovery following her surgery at NYU Langone, but the organ had to be removed after 47 days, and she passed away in July.
Looney, however, was not terminally ill before the transplant, noted Robert Montgomery, who led the surgery. Each case, he emphasized, provides critical lessons for refining the techniques.
The kidney was provided by biotech company Revivicor, which breeds genetically modified herds in Virginia. A Massachusetts-based company, eGenesis, provided the kidney for Slayman.
Looney’s organ has 10 genetic edits to improve compatibility with the human body — an advance over Revivicor’s earlier efforts that used kidneys with a single gene edit and included the pig’s thymus gland to help train the host’s immune system and prevent rejection.
Montgomery, a pioneer in the field who performed the world’s first gene-edited pig organ transplant in a brain-dead patient in 2021, said both methods are likely to enter clinical trials “probably by this time next year, or even sooner.”
“This is a watershed moment for the future of transplantation,” said Kevin Longino, CEO of the National Kidney Foundation. The nonprofit’s polling shows that patients and families favor faster clinical trial progress, believing the risk of inaction outweighs the uncertainties of xenotransplantation.
Looney was discharged December 6 to a nearby New York City apartment. Though her high antibody levels remain a concern, doctors are monitoring her closely using wearable technology and are trying a novel drug regimen to prevent rejection.
Periodic hospital visits may still be required, but the team remains optimistic she can return home in three months.
AFP
Health
New York Doctor Sued For Mailing Abortion Pills To Texas Woman
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The Republican attorney general of Texas has filed a lawsuit against a New York doctor who mailed abortion pills to a woman in the southern state.
Texas has some of the toughest laws restricting abortion in the country, and the case pits state laws regulating the procedure against each other.
Texas Attorney General Ken Paxton filed the civil suit on Thursday against Margaret Carpenter, the New York-based founder of the Abortion Coalition for Telemedicine.
The attorney general’s office said Carpenter provided a 20-year-old Texas woman with “abortion-inducing drugs that ended the life of an unborn child and resulted in serious complications for the mother.”
“Texas laws prohibit a physician or medical supplier from providing any abortion-inducing drugs by courier, delivery, or mail service,” it said.
In addition, “no physician may treat patients or prescribe Texas residents medicine through telehealth services unless the doctor holds a valid Texas medical license.”
Carpenter is not a licensed physician in Texas.
Texas is seeking an injunction against Carpenter barring her from illegally practicing medicine in the state and from prescribing abortion pills to Texas residents.
He is also seeking a $100,000 fine for each violation.
“In Texas, we treasure the health and lives of mothers and babies, and this is why out-of-state doctors may not illegally and dangerously prescribe abortion-inducing drugs to Texas residents,” Paxton said.
Democratic-controlled New York has passed a so-called shield law which provides legal protection to New York doctors who send abortion pills to women in states where the procedure has been outlawed.
Eighteen Democratic-ruled states have enacted shield laws since the US Supreme Court struck down the nationwide right to abortion in 2022, according to the Center for Reproductive Rights.
In June of this year, the top court rejected a bid by anti-abortion groups to restrict mifepristone, the pill widely used to terminate pregnancies in the United States.
The Texas lawsuit raises thorny legal questions for the courts about what is known as extraterritoriality, the application of one state’s laws to another.
AFP
Health
Malaria Vaccine Receives High S ores In Latest Treatment Evaluation Study
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Malaria Vaccine Receives High Marks In Latest Treatment Evaluation StudyThe R21 malaria vaccine has been prequalified by the World Health Organization (WHO), offering an affordable and promising solution for malaria control in Africa, according to a recent study published by 1Day Africa, a global non-profit organization. The study emphasizes that the vaccine’s cost-effectiveness is comparable to that of insecticide-treated bed nets, which have long been a cornerstone in malaria prevention.
The report reveals that the R21 vaccine costs $39 per disability-adjusted life year (DALY) averted, closely rivaling the $38 cost of bed nets. In contrast, the RTS malaria vaccine costs $129 per DALY, making R21 a more cost-efficient option for large-scale distribution in low- and middle-income countries.
Produced by the Serum Institute of India, the R21 vaccine benefits from streamlined manufacturing processes, which contribute to its reduced cost. Researchers suggest that combining R21 with other malaria control measures, such as seasonal chemoprevention and vector control programs, could significantly reduce malaria cases in Sub-Saharan Africa, where the majority of global malaria incidents occur.
Malaria remains a significant public health challenge, with 95% of the world’s cases reported in Sub-Saharan Africa in 2022. The introduction of the R21 vaccine, according to the study, could reshape malaria control efforts, especially in regions facing rising resistance to traditional prevention methods.
The report calls for continued investment in malaria research and the integration of new interventions like R21 into comprehensive public health strategies to tackle the disease more effectively.
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