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‘Blessed’: US Woman Sees Second Chance In Life After Pig Kidney Transplant

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Towana Looney donated a kidney to her mother in 1999 only for the remaining one to fail years later due to pregnancy complications.

Now, the 53-year-old from Alabama has become the latest recipient of a gene-edited pig kidney — and is currently the only living person in the world with an animal organ transplant, New York’s NYU Langone hospital announced Tuesday.

“I’m overjoyed, I’m blessed to have received this gift, this second chance at life,” Looney said during a press conference, held three weeks after the procedure.

Xenotransplantation, transplanting organs from one species to another, has long been a tantalizing yet elusive scientific goal. Early experiments on primates faltered, but recent advances in gene editing and immune system management have brought the dream closer to reality.

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Pigs have emerged as the ideal donors: they grow quickly, produce large litters and are already part of the human food supply.

Advocates hope this approach can help address the severe organ shortage in the United States, where more than 100,000 people are waiting for transplants, including over 90,000 in need of kidneys.

A last chance

Looney had been living with dialysis since December 2016 — eight grueling years. High blood pressure caused by preeclampsia had taken its toll, leaving her with chronic kidney disease.

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Despite receiving priority on transplant waiting lists as a living donor, her search for a compatible kidney was a frustrating dead end. Her unusually high levels of harmful antibodies made rejection almost inevitable, and as her body lost viable blood vessels to support dialysis, her health declined.

Out of options, Looney applied to join a clinical trial for pig kidney transplants, and finally underwent the seven-hour surgery on November 25.

Asked how she felt afterward, Looney’s joy was infectious. “I’m full of energy, I’ve got an appetite… and of course, I can go to the bathroom. I haven’t been going in eight years!” she laughed, adding that she plans to celebrate at Disney World.

Jayme Locke, a surgeon on the transplant team, described the results with awe. “The kidney functioned essentially exactly like a kidney from a living donor,” she said, adding that Looney’s husband saw a rosiness in her cheeks for the first time in years.

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“That is the miracle of transplantation.”

Cautious optimism

Looney’s surgery is the third time a gene-edited pig kidney has been transplanted into a human who is not brain dead.

Rick Slayman, the first recipient, died in May, two months after his procedure at Massachusetts General Hospital. The second, Lisa Pisano, initially showed signs of recovery following her surgery at NYU Langone, but the organ had to be removed after 47 days, and she passed away in July.

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Looney, however, was not terminally ill before the transplant, noted Robert Montgomery, who led the surgery. Each case, he emphasized, provides critical lessons for refining the techniques.

The kidney was provided by biotech company Revivicor, which breeds genetically modified herds in Virginia. A Massachusetts-based company, eGenesis, provided the kidney for Slayman.

Looney’s organ has 10 genetic edits to improve compatibility with the human body — an advance over Revivicor’s earlier efforts that used kidneys with a single gene edit and included the pig’s thymus gland to help train the host’s immune system and prevent rejection.

Montgomery, a pioneer in the field who performed the world’s first gene-edited pig organ transplant in a brain-dead patient in 2021, said both methods are likely to enter clinical trials “probably by this time next year, or even sooner.”

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“This is a watershed moment for the future of transplantation,” said Kevin Longino, CEO of the National Kidney Foundation. The nonprofit’s polling shows that patients and families favor faster clinical trial progress, believing the risk of inaction outweighs the uncertainties of xenotransplantation.

Looney was discharged December 6 to a nearby New York City apartment. Though her high antibody levels remain a concern, doctors are monitoring her closely using wearable technology and are trying a novel drug regimen to prevent rejection.

Periodic hospital visits may still be required, but the team remains optimistic she can return home in three months.

AFP

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FG to employ 28,000 health workers affected by USAID freeze

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The Federal Government has announced plans to retain 28,000 health workers whose salaries were previously covered by the United States Agency for International Development (USAID), whose activities have been halted by US President Donald Trump.

Nigeria’s Coordinating Minister of Health and Social Welfare, Muhammad Pate, while speaking on Channels Television’s Hard Copy programme, on Friday, announced that the government is working to absorb the health workers into the country’s healthcare system and reduce reliance on foreign aid.

Mr Pate acknowledged the significant contribution of the US government to Nigeria’s healthcare sector, particularly in the areas of HIV, Tuberculosis, and Malaria.

He, however, emphasised that Nigeria is determined to take ownership of its healthcare sector and reduce its dependence on external aid.

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“There are health workers, 28,000 of them, who were being paid through US government support. While it has been appreciated, those health workers are Nigerians. We have to find ways to transit them,” he said.

Apart from suspending the USAID which supports healthcare and other development activities across the world, President Trump has also halted the President’s Emergency Plan for AIDS Relief (PEPFAR), which supports the global fight against HIV/AIDS.

Following his inauguration on 20 January, President Trump signed multiple executive orders affecting global health funding and significantly impacting developing countries like Nigeria that rely on US assistance for health financing.

Mr Trump signed an order to halt the disbursement of foreign aid to any country for three months. The implementation of this order halted the US global health efforts, including PEPFAR, in low and middle-income countries around the world.

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Although PEPFAR was issued a limited waiver a week later, allowing it to restart some services, the situation has remained fluid. PEPFAR is a major programme through which HIV interventions in Nigeria are funded.

The situation was also worsened by the US government’s decision to suspend USAID’s activities. The agency implements many US health programmes in Nigeria and other developing countries.

All USAID interventions in Nigeria and across the world have been suspended with the American president’s team, led by billionaire Elon Musk, saying they are auditing the agency to check waste and corruption in the system.

To mitigate the impact of the US policy shift, the Nigerian Senate recently allocated an additional N300 billion to the health sector in the 2025 budget. This additional budgetary allocation is expected to take care of the 28,000 health workers, among other issues in the sector.

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According to Mr Pate, about 70 per cent of the country’s total health expenditure comes from private sources, including out-of-pocket payments by citizens, while only 30 per cent is publicly financed.

“Our total health spends in Nigeria, the total health expenditure: 30 per cent is public, 70 per cent is private,” he said, emphasising the financial burden on individuals seeking medical care.

While external assistance has played a role in supporting healthcare programmes, the minister noted that it is not the primary source of Nigeria’s health funding.

“The component of overseas development assistance for health is not the largest chunk of our health expenditure,” he stated.

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However, the reliance on foreign aid for critical services such as HIV, TB, and malaria has made the country vulnerable to shifts in donor policies, as seen with the recent changes in US government funding.

Mr Pate stressed the need for increased domestic investment in healthcare, citing President Bola Tinubu’s Renewed Hope Agenda, which prioritises human capital development and increased healthcare funding.

He highlighted the government’s recent approval of nearly $1 billion to improve health service delivery across the country.

“We’ve seen deliberate efforts to mobilise resources to invest in health. Just last week, the Federal Executive Council approved almost a billion dollars in terms of financing for the programme. That is a significant resource that states will implement. It’s a programme for results that will deliver better, but it will take time,” he said.

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Mr Pate further highlighted that the government is working to address Nigeria’s heavy dependence on imports for its pharmaceutical needs, noting that the country imports the vast majority of its medical supplies.

“Can you believe that more than 70 per cent of our drugs, we import with foreign exchange that we didn’t have? So, if we can flip it over time. 99 per cent of our medical devices, we import them,” he said.

He acknowledged that reversing this trend will not happen overnight but emphasised that the government is committed to changing the trajectory.

He pointed to efforts aimed at increasing local production of essential medical commodities, including antibiotics, as part of a broader strategy to strengthen Nigeria’s healthcare system.

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“Now, if we flip that over time, that is not going to take place overnight, but we have to be on that path,” he added.

“Healthcare is not cheap. Quality healthcare is not cheap. You have to invest in it. We as a country had not invested in it, and yet we had been asking for the highest quality health.”

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NAFDAC discovers depot for expired drugs in Abia

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The National Agency for Food and Drug Administration and Control (NAFDAC) on Friday uncovered a major operation depot dealing in expired and falsified drugs at Umumeje village, Osisioma Ngwa area of Abia State.

NAFDAC disclosed this in a statement on X, saying it revealed that the illegal operation was being run from multiple buildings near the Ariaria International Market.

According to the agency, the expired medicines were repackaged and revalidated for resale, posing a significant health risk to consumers.

“Seized items consisted of expired potassium chloride, allergy medications, immune boosters, and cholesterol treatments,” the statement read.

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“Machines used to rebrand and alter expiry dates were also discovered on-site. Despite efforts to reach him, he showed no concern for his detained family members,” the statement read.

The raid led to the arrest of several individuals associated with the operation. However, the prime suspect behind the illicit trade remains at large.

https://twitter.com/NafdacAgency/status/1890352992877949031?ref_src=twsrc%5Etfw

NAFDAC stated that the operation, conducted in collaboration with security agencies, is part of the Federal Government’s ongoing crackdown on the circulation of counterfeit drugs in the country.

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The agency also reaffirmed its commitment to eradicating the distribution of substandard and falsified drugs in Nigeria, saying it is is currently reviewing its laws to impose stricter penalties on individuals and organisations involved in the production and distribution of dangerous pharmaceutical products.

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Sokoto warns parents resisting polio immunisation

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Sokoto State has issued a stern warning to parents resisting polio immunisation, stressing that non-compliance will not be tolerated in the state’s fight to eradicate the disease.

In a directive aimed at curbing resistance, the state has mandated its officials to report any cases of parents hindering immunisation efforts during vaccination campaigns.

The directive was announced by Sokoto’s Deputy Governor, Idris Gobir, at a United Nations Representatives’ meeting held on Wednesday at the Command Guest Inn in Sokoto.

The meeting included local government chairmen, religious leaders, and traditional rulers.

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Gobir’s announcement followed a report from the state’s Commissioner of Health, Dr. Faruk Abubakar, highlighting ongoing challenges in the battle against polio, including non-compliance from some parents and inaccuracies in data collection during immunisation drives.

“We already have a standing committee and sub-committees at the local and ward levels that are focused on tackling resistance to polio immunisation. Our government has the necessary resources, personnel, and capacity to eliminate the virus, but despite our efforts, the continued presence of polio in Sokoto remains a serious concern,” Gobir stated.

In her address, the UNICEF Country Representative in Nigeria, Mrs. Christian Munduate, expressed concern over the rising number of polio cases in Sokoto North and South, warning that these areas have the highest number of polio infections in the country.

She also raised alarm about the widespread issue of fake fingerprint markings, where some parents and vaccinators falsely claim that children have been immunised, undermining efforts to eradicate the disease.

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Munduate called for increased collaboration between government agencies, traditional leaders, and international partners to address these persistent challenges and ensure the success of immunisation campaigns.

The meeting saw contributions from various stakeholders, including a representative of the Sultan of Sokoto and District Head of Wurno, Kabir Alhassan, and the Chairman of the House of Assembly Committee on Health, Kabir Dauda, who delivered goodwill messages reinforcing the importance of collective action in the fight against polio.

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